In a recent meta-analysis on Fe and Fe regulating proteins in ALS, however, no significant difference in Fe levels between ALS patients and healthy controls could be calculated, yet serum ferritin levels were found higher and transferrin levels lower in the overall assessment [128], indicating a possible use for ferritin as an ALS biomarker, and for transferrin as a potential treatment. Here, TF is linked to amyotrophic lateral sclerosis.