The aim of our study was to evaluate the importance of IGFBP-7 as a potential marker of symptomatic PAD occurrence, to evaluate the correlation of IGFBP-7 concentration with classical cardiovascular risk factors in this group of patients, and to assess the usefulness of IGFBP-7 as a prognostic marker after lower limbs arteries revascularization. Here, IGFBP7 is linked to peripheral arterial disease.