Upregulation of miR-221-3p in a mouse kidney cancer model was not transferred through exosomes to cells of TME and we did not observe changes in PTEN expression in mature brain-derived endothelial cells, but in cervical cancer, cell-secreted exosomal miR-221 promoted angiogenesis through Thrombospondin-2 [72]. Here, THBS2 is linked to kidney cancer.