DRD2 and early-onset autosomal dominant Alzheimer disease: Though, with our assay conditions, PIM displayed a good affinity at 5-HT6 and a weak affinity at D2R. Since 5-HT6 antagonists are already under investigation for cognitive improvements in patients diagnosed with Alzheimer’s disease (AD) [50], this might contribute to a potential use of PIM and its derivatives for AD.