Our previous study showed that nuclear contents of TFEB, as well as the phosphorylation levels of ribosomal protein S6 kinase β-1 (S6K), a classic target for mTORC1, are both oscillated in the liver during long-term HFD feeding, indicating that mTORC1 signaling and TFEB activity are dynamically altered by overnutrition [100]. The gene discussed is TFEB; the disease is overnutrition.