Within the nucleus, the TGFβRI-ICD promotes the transcription of TGF-β and TGFβRI itself, as well as pro-invasive genes such as SNAIL1 and MMPs, further promoting the activity of TGF-β in this positive forward signaling loop, leading to enhanced EMT, conferring migratory and invasive capabilities on cancer cells. The gene discussed is TGFB1; the disease is cancer.