Yet another way to regulate function of TGFβ signaling is exemplified by the fact that TGFβRI undergoes proteolytic cleavage by the activated disintegrin and metalloprotease 17 (ADAM17)/tumor necrosis factor-α-converting enzyme (TACE), and thereby TGF-β can no longer cause growth inhibition in cancer cells [42]. This evidence concerns the gene TGFB1 and cancer.