Distinct from the two main types of diabetes mellitus (DM), type 1 diabetes mellitus (T1DM) (described by the presence of autoantibodies against insulin-producing pancreatic β-cells and the absence of insulin secretion) and type 2 diabetes mellitus (T2DM) (with peripheral insulin resistance, no autoantibodies, and impaired insulin secretion), a new category was defined, type 3c diabetes (T3cDM), or pancreatogenic or pancreoprivic diabetes mellitus, which has been reported to account for 9% of patients hospitalized with diabetes [1,2]. This evidence concerns the gene INS and Insulin resistance.