In the multivariate analysis, we observed that podoplanin score (with combination of extent and intensity) presented an independent association on the risk of transformation to oral cancer (p = 0.017; HR of 10.148, 95% CI of 1.503–68.532), while binary dysplasia grade reached marginal significance (p = 0.054; HR of 9.316, 95% CI of 0.965–89.951). Here, PDPN is linked to lip and oral cavity carcinoma.