Inflammation persisted even after RAMP2 gene deficiency was induced, and prior to tumor metastasis we observed increased expression of S100A8/A9 and its downstream factor, SAA3, which are known to recruit tumor cells to metastatic sites [23,24], suggesting that they may promote pre-metastatic niche formation in the target organ (Figure 4; right). This evidence concerns the gene S100A8 and neoplasm.