In a clinical study, Zaidi et al. [18] investigated the effects of long-term combined exercise (60 min/day, 2 times/week for 12 months); aerobic (interval running/step training and spinning (rated perceived exertion ≥15; 5–15 min duration) and resistance training (free weights for large muscle groups at moderate intensity) on the remodeling markers MMP-9, TIMP-1, protein extracellular matrix metalloproteinase inducer (EMMPRIN), and galectin-3 in the subcutaneous adipose tissue of patients with type 2 diabetes mellitus and coronary artery disease. The gene discussed is BSG; the disease is diabetes mellitus.