As inflammatory cytokines and inflammasomes, such as IL-6, IL-1β, or NLRP3, has been established to be major players in the condition of acute myocardial infarction, and ET-1, as has been mentioned previously, correlates strongly with inflammation, both as an inducer of cytokine expression and as one of the secreted factors after exposure to inflammation [208,227]. This evidence concerns the gene EDN1 and myocardial infarction.