The exception was reported by Wei et al. [35]; non-osteogenic exosomes were able to improve ALP activity and osteogenic marker expression (OPN, ALP, RUNX2, BMP2, and BMP7) in BMSCs cultured in OM compared to exosomes derived from 3, 7, and 14 days of osteogenic induction. Here, SPP1 is linked to ocular melanoma.