Exosomes derived from miR-375-overexpressing ASCs showed improvement in the ALP activity, mineral deposition, and osteogenic marker expression (RUNX2 and OCN) of BMSCS cultured in PM and OM compared to non-modified exosomes; ALP and COL1A1 were upregulated only when BMSCs were cultured in OM [38]. This evidence concerns the gene BGLAP and ocular melanoma.