Notable examples of overlapping transcripts included the gene encoding thrombospondin 4 (THBS4), which was down-regulated 2.6-fold in GGF2-treated swine (p = 0.001) and up-regulated in denervated animal muscles (1.6-fold, p = 0.048) and in humans with Pompe (2-fold, p = 0.046), tibial muscular dystrophy (3.1-fold, p = 0.011), iron-sulfur cluster myopathy (2-fold, p = 0.046) and old age (1.6-fold, p = 0.039). The gene discussed is THBS4; the disease is tibial muscular dystrophy.