GGF2 also induced the expression of genes that are down-regulated in humans and/or animal experimental models of myopathy, including KLF10 (encodes Kruppel-like factor 10), purinergic receptor P2Y (P2RY1), the gene encoding the lactate transporter MCT4 (SLC16A3), retinoid receptor γ (RXRG), triadin (TRDN), myosin heavy chain (MYH1), epidermal growth factor (EGF), and the skeletal muscle isoform of phosphorylase kinase (PHKA1) that when mutated causes muscle glycogenosis (Figure 5b). Here, TRDN is linked to myopathy.