We therefore compared GGF2-altered genes to four animal models of skeletal myopathy and 11 human myopathies (Table 2) and found 230 cachexia transcripts reversibly altered in GGF2-treated pigs (e.g., up-regulated in myopathic skeletal muscle and down-regulated in GGF2-treated pigs). This evidence concerns the gene NRG1 and myopathy.