S100A11 and hepatocellular carcinoma: Proteome and transcriptome analyses of the contents within HCC-derived exosomes showed that they retained numerous oncogenic factors, such as caveolin, RAS related, S100A4, and S100A11, which promoted migration and invasion of immortalized hepatocytes by activating PI3K/AKT and MAPK signaling and increasing the secretion of active matrix metalloproteinases (MMP)-2 and MMP9 [119].