The polyherbal, compared to choline chloride, reduced the expression of genes of the renin–angiotensin system (Fc: 3.4, p = 0.03; Table 5), the digestion and absorption of carbohydrates (Fc: 3.3, p = 0.02; Table 6), and the peroxisome proliferator-activated receptor signaling pathways (PPAR, Fc: 2.5, p = 0.02, Table 5), implied in the group of cardiovascular and metabolic diseases prevention (Table 4). The gene discussed is REN; the disease is metabolic disease.