Genes that were underexpressed by the polyherbal included: hematopoietic and lymphoid tissues, such as acute myeloid leukemia (IL3, RUNX1T1, CD14, BCL2A1), B lymphoblastic lymphoma (ETV6, IL3, ELANE, KMT2A, MLLT3, HMGA2, KDM6A), T lymphoblastic lymphoma (KMT2A, MLLT3, CDKN2C, HHEX), Hodgkin lymphoma (C-REL, BCL2A1, TRAF1), and multiple myeloma (NSD2, HIST1H3G, ITGB7); epithelial cancers, such as prostate cancer (PLAU, MMP3, MMP9); neuroendocrine cancers, such as neuroblastoma (PTK2, BMI1), carcinoid (KMT2A), and Ewing’s sarcoma (FLI1, ID2, TGFBR2). This evidence concerns the gene REL and Familial prostate cancer.