For example, ratios of lymphocytes to neutrophils were associated with immunohistochemically determined Ki-67 index in the following two recent human medical studies on glioma and on adrenocortical carcinoma, and elevated ratios and elevated Ki-67 indices were associated with higher pathologic grades or increased risk of tumour recurrence [19,21]. This evidence concerns the gene MKI67 and adrenal cortex carcinoma.