Using ratios of serum Ki-67 concentrations and the aforementioned inflammatory parameters for the ROC curve to distinguish non-neoplastic diseased dogs from tumour-diseased dogs, the AUC improves as follows: the comparison of the Ki-67–neutrophil ratio provides an AUC of 0.73 (p = 0.0005; 95% confidence interval, 0.63–0.83), with a sensitivity of 68.8% (confidence interval, 0.58–0.78) and a specificity of 61.5% (confidence interval, 0.43–0.78), when using a cut-off value of 0.24 (Figure 10A). The gene discussed is MKI67; the disease is neoplasm.