LRRK2 and Parkinson disease: Since R1441C and Y1669C mutations in leucine-rich repeat kinase 2 (LRRK2) are the pathogenic LRRK2 mutants in sporadic PD, a Drosophila model that expressed the LRRK2 mutants (R1441C and Y1669C) has been used to investigate the role of HDAC6 in PD [66,67,68,69,70,71].