Four major genes have been identified as causative of motor neuron degeneration: C9orf72 (Chromosome 9 open reading frame 72), SOD1 (Cu2+/Zn2+ superoxide dismutase), TARDBP (TAR DNA binding protein) and FUS (RNA binding protein Fused in Sarcoma) [6,7]. Here, TARDBP is linked to Motor neuron atrophy.