MAPK8 and Anxiety: As shown in Figure 9, ACG has an anti-anxiety effect by regulating the prolactin signaling pathway, estrogen signaling pathway, and ARA metabolism pathway through ALB, AKT1, PTGS2, CYP3A4, ESR1, CASP3, CYP2B6, EGFR, SRC, MMP9, IGF1, and MAPK8, thus directly or indirectly affecting the levels of neurotransmitters in the brain and peripheral HPA axis hormones.