Through ALB, AKT1, PTGS2, CYP3A4, ESR1, CASP3, CYP2B6, EGFR, SRC, MMP9, IGF1, MAPK8, and other targets, ACG in the 95% ethanol extract of ZZX could regulate the prolactin signaling pathway, estrogen signaling pathway, and ARA metabolism pathway, thereby directly or indirectly affecting the brain neurotransmitter levels and HPA axis hormone levels to exert an anti-anxiety mechanism. Here, MAPK8 is linked to Anxiety.