APOE and Mental deterioration: There are a few large-sample studies about the joint effect of hypertension and APOE-related cognitive decline, such as the Personality and Total Health (PATH) through Life project [25], the Honolulu-Asia Aging Study [26] and the Tone Project [19], and these studies have shown that hypertensive patients with APOE ε4 carriers can aggravate cognitive decline, especially in cognitive flexibility, working memory and episodic memory.