ACE2 and atherosclerosis: Consistent with this latter hypothesis, in this paper we show that selectively increasing circulating soluble ACE2 using two different approaches, either recombinant murine ACE2 (rmACE2) or intramuscular injection of DNA minicircles encoding soluble ACE2, attenuates vascular inflammation, oxidative stress, and atherosclerosis in a susceptible pro-atherosclerotic murine model.