SELENOS and early-onset autosomal dominant Alzheimer disease: Studies have found that selenoproteins can lead to impaired cognitive function and neural systemic disease [41,42,43]; existing research has shown that selenoproteins in brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), play an important role in epilepsy [44,45,46].