In SCD, Prx2 has been also shown to be involved in the dynamic cross-talk between the cytoplasm compartment and the RBC membrane of SCD mice exposed to hypoxia-reoxygenation stress, a condition used to mimic acute sickle cell-related vaso-occlusive crisis (VOC) [101,102,116]. The gene discussed is PRDX2; the disease is Schnyder corneal dystrophy.