Compound I, ((Z)-2-(2,4-dihydroxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one), also had a low IC50 value (5.0 ± 0.38 μM) against mushroom tyrosinase and exhibited anti-tyrosinase and anti-melanogenic effects in B16F10 murine melanoma cells [32]. Here, TYR is linked to melanoma.