AGER and metabolic dysfunction-associated steatohepatitis: However, the study results suggest that the hepatocyte toxicity of AGEs is less severe than for the AGE–RAGE system; however, interestingly, Bijnen et al. (2018) found that RAGE deficiency showed no effect on the pathogenesis of non-alcoholic steatohepatitis and atherosclerosis in hyperlipidemic/Ldlr knockout mice.