The OGG1-8-oxoG complex can also increase the level of Rho-GTP in cells (such as fibroblasts and epithelial cells), thereby mediating the polymerization of α-smooth muscle actin (α-SMA) into stress fibers and increasing the level of α-SMA in insoluble cells/tissue and participating in lung remodeling and fibrosis (including idiopathic pulmonary fibrosis) [96]. This evidence concerns the gene ACTA1 and pulmonary fibrosis.