OGG1 and cancer: On the contrary, it was observed that OGG1 mutant mice manifested an increased susceptibility to the multiorgan carcinogenesis induced by N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH) (DMBDD) [105], and OGG1 depletion suppressed A3 T-cell lymphoblastic acute leukemia growth, both in vitro and in vivo, suggesting that OGG1 could play a role as a potential anti-cancer target [106].