Another study showed that the use of melatonin in gestation and lactation prevented hypertension programmed by a combined high-fructose plus post-weaning high-salt diet via regulating SIRT1, SIRT4, AMPKα2, AMPKβ2, PPARγ, and PGC-1α in the kidneys [91]. The gene discussed is PPARG; the disease is Hypertension.