Several nutrient-sensing signals are involved in the early life origins of hypertension, including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs), silent information regulator T1 (SIRT1), and PPARγ co-activator 1α (PGC-1α) [110,111]. This evidence concerns the gene PRKAA2 and hypertensive disorder.