Furthermore, supplementing with selenium and magnesium inhibits the mRNA expression level of hepatic lipogenesis genes liver X receptor alpha (LXRα), SREBP-1c, and FASN (fatty acid synthase) to reduce the hepatic total cholesterol (TC) and attenuate liver steatosis in the rats fed by high-fat diet [47]. The gene discussed is NR1H3; the disease is Hepatic steatosis.