PLAGL2 and hepatocellular carcinoma: Yang et al. found that selenium sulfide (SeS2) suppressed C-MET/STAT3, AKT/mTOR, and MAPK signaling and prompted Bcl-2/Cyto C/Caspase-mediated intrinsic mitochondrial apoptosis in HCC cells in a PLAGL2-dependent manner by triggering Bcl-2/Cyto C/Caspase-mediated intrinsic mitochondrial apoptosis in a PLAGL2-dependent manner [68].