In addition, a study in hepatoma cells confirmed that AMPK activation downregulated the expression of sterol regulatory element binding protein 1 (SREBP1) and its downstream gene, stearoyl-CoA desaturase-1 (SCD1), as well as reduced the synthesis of mono-unsaturated fatty acids and promoted the occurrence of ferroptosis [109]. Here, SREBF1 is linked to hepatocellular carcinoma.