EIF2AK3 and glaucoma: Hu et al. showed that inhibition of the PERK-eIF2α-CHOP pathway and activation of XBP1 can protect RGC soma and axons in mouse models of glaucoma, but in 2019, Marola et al. demonstrated that CHOP deletion alone, while conferring mild protection to RGCs, did not prevent axonal degeneration [193,194].