Variants of genes identified in the pathogenesis of glaucoma which are common but have a low effect size in the development of glaucoma include TMCO1, Cyclin-dependent kinase inhibitor 2B (CDKN2B-AS1 or ANRIL), Caveolin 1 (CAV1), Caveolin 2 (CAV2), Sine Oculis Homeobox Homolog 1 (SIX1), Sine Oculis Homeobox Homolog 6 (SIX6), Growth Arrest Specific Protein 7 (GAS7), Atonal BHLH Transcription Factor 7 (ATOH7) and RPGR Interacting Protein 1 (RPGRIP1) [161,162,163,164,165,166,167,168,169]. The gene discussed is SIX1; the disease is glaucoma.