In 2018 they showed that in glaucoma induced by glucocorticoid use, increased extracellular matrix (ECM) deposition and ER stress were induced through TGFβ signalling, and interestingly, knockdown of ATF4 or CHOP completely prevented this signalling, thereby preventing ECM deposition and ER stress in mouse models of TM [175]. The gene discussed is DDIT3; the disease is glaucoma.