TAC Ldlr−/−Cbs+/− mice fed with a methionine-rich, folate-deficient diet to establish mild hyperhomocysteinemia presented with worsened cardiac hypertrophy, diastolic dysfunction, interstitial fibrosis, and apoptosis than control TAC mice fed with a standard chow and diet AdCBS TAC mice. The gene discussed is LDLR; the disease is cardiac hypertrophy.