NFE2L2 and heart failure: The evaluation of a phase 3 clinical trial with bardoxolone methyl, an Nrf2 inducer, in diabetic patients with chronic kidney disease was terminated prematurely on the recommendation of the safety monitoring committee due to the strong adverse safety signals associated with the treatment, such as increased rates of heart failure, cardiovascular events, high blood pressure levels, heart rate, and albuminuria compared with the placebo group [110].