Glrx inhibits Fas signaling, protects lung epithelial cells from apoptosis, and attenuates experimental lung fibrosis [27], and can mediate anti-apoptotic effects by activating NFκB [28,38,39] or SirT1 [25,40] via the reversal of S-glutathionylation. This evidence concerns the gene NFKB1 and pulmonary fibrosis.