Here, HFD- and SRHFD-fed mice revealed similar insulin resistance (HOMA-IR, HFD = 8.6 vs. SRHFD = 11.7, p = 0.258) and insulin sensitivity scores (Matsuda Index, HFD = 2.6 vs. SRHFD = 2.3, p = 0.5972) (Figure 6a,b). This evidence concerns the gene INS and Insulin resistance.