Furthermore, IL-6 and TNF-α, which are significantly downregulated and inhibited by APEX, are among the major pathogenetic actors of CIBD [54]; IRAK-1, targeted by APEX, has been found to be involved in ulcerative colitis and Crohn’s disease, and it is increasingly expressed during the active phases of these conditions [55]. This evidence concerns the gene IRAK1 and Crohn disease.