SOD1 and obesity due to melanocortin 4 receptor deficiency: We assessed the impact of HFD-induced obesity and polyphenols on redox markers during stroke by evaluating the level of the protein Nrf2 known as a key redox-sensitive transcriptional factor regulating the production of redox enzymes, and the activity of SOD recognized as a first line of the endogenous enzymatic antioxidant defense system.