Thus, COX2 can be induced by Ang II in VSMCs [48] and can enhance Ang II-induced [47] and renovascular hypertension [29] in some studies; yet, COX products can moderate hypertension in others [49] and a COX blockade with non-steroidal anti-inflammatory agents usually increases the BP of patients with hypertension. Here, PTGS2 is linked to renovascular hypertension.