12b was demonstrated to bind to TfR1 directly and cause iron deprivation as well as dysregulation of the intracellular oxidative environment, in turn inducing degradation of FGFR1 oncoprotein through proteasome pathway and TfR1-related cell apoptosis in MDA-MB-231 breast cancer cells. This evidence concerns the gene FGFR1 and breast carcinoma.