In all, 12b as a Muriceidine A derivative, was demonstrated to bind to TfR1 directly and cause iron deprivation as well as dysregulation of the intracellular oxidative environment, inducing degradation of FGFR1 oncoprotein through proteasome pathway and TfR1-related cell apoptosis in MDA-MB-231 breast cancer cells. Here, TFRC is linked to breast cancer.