TFRC and central nervous system cancer: The murine anti-human TfR1 IgG antibody 7579 downregulates TfR1 surface levels on cancer cells and has shown inhibitory effects on proliferation as well as inducing apoptosis of human U87MG, U251, and A172 glioma cells in vitro [19]; JST-TFR09, an antibody to human TfR1, has a great affinity to TfR1 in adult T-cell leukemia/lymphoma cells.