MAPT and Alzheimer disease: Regarding tau pathology, immunofluorescence and immunoblot analysis using the anti-phospho-tau antibody AT8 (pS202-tau) revealed a significant increase in hyperphosphorylated tau in 3×Tg-AD mice and a significant reduction in hyperphosphorylated tau in Se-FA-treated AD mice compared to their corresponding controls (Figure 5d–f).