PPARD and neurodegenerative disease: Although the function of the PPARδ in the pathogenesis of PD is not fully elucidated, the present findings clearly indicate that activation of PPARδ with GW501516 attenuates 6-OHDA-induced neuronal damage in SH-SY5Y neuroblastoma cells, indicating the potential therapeutic potential of PPARδ as a novel approach to treatment for neurodegenerative diseases, particularly PD.