Although the precise molecular mechanisms of PPARδ-mediated neuroprotection from 6-OHDA are lesser known than its roles in cellular inflammation and metabolism [22], the present observations are consistent with a previous report demonstrating that PPARδ improves motor impairment and dopaminergic neurodegeneration by inhibiting neuroinflammation in the MPTP mouse model of PD [28]. The gene discussed is PPARD; the disease is Parkinson disease.