On the other hand, the third highest SNP rs17174795 is located 1.4 kb apart from PTPRO (Protein Tyrosine Phosphatase Receptor type O), which has been suggested as a candidate tumour suppressor via the NF-Kappa B signalling pathway [76,77], and the transcription factor NF-Kappa B plays a central role in inflammatory airway diseases such as asthma [78]. The gene discussed is PTPRO; the disease is asthma.