IGHE and allergic disease: Loli-Ausejo et al. reported no anaphylaxis and attributed the symptoms to non-IgE-mediated mechanisms [28]; the CDC reported 83 cases of mild cutaneous or respiratory reactions (0.0044%) and 21 cases of anaphylaxis with Comirnaty® [38]; and Blumenthal et al. described 1.95% of acute allergic reactions and a rate of 2.47 cases of anaphylaxis per 100,000 doses administered [35].