Genome wide association studies (GWAS) and later other studies have reported that PNPLA3 gene polymorphism I148M (rs738409, C > G) is strongly associated with the full disease spectrum of NAFLD, including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma [3, 4]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.