The findings in this section show that VX765 can rescue the neuroinflammation and neurotoxicity caused by GPR120-AAV-KD in the hippocampus of epileptic mice, indicating that GPR120 could regulate neuroinflammation in epilepsy which in turn affect neuronal damage through the activation of NLRP3 inflammasome complex. This evidence concerns the gene NLRP3 and epilepsy.