Since the role of GPR120 in epilepsy has not been studied or fully illustrated, it is unclear whether its involvement in epilepsy is associated with the activation of NLRP3-mediated neuroinflammation, we set out this study to investigate the expression pattern of GPR120 in the brain of animal model of epilepsy and its specific role in regulating neuroinflammation and neuronal survival. Here, FFAR4 is linked to epilepsy.