One of the ways to increase specificity for the detection of high-grade cervical disease and identify markers of its evolution, is to look for the expression of viral oncogenes E6/E7 [23], by directly testing E6/E7 mRNA in the lesion (HPV E6/E7 mRNA test) and indirectly by dosing the p16 protein, Kinase-Cyclic dependent inhibitor (p16 protein test): its increase indicates that the virus's E7 oncogene degraded the pRb protein by precipitating the cell towards oncogenesis. The gene discussed is RB1; the disease is cervicitis.