The guideline describes packages related to TB disease among advanced HIV patients to involve (i) Sputum Xpert MTB/RIF as the first test for TB diagnosis among symptomatic people, (ii) Lateral Flow Urine Lipoarabinomannan Assay (LF-LAM) for TB diagnosis among people with symptoms and signs of TB, (iii) TB preventive treatment (IPT) offered to all patients regardless of CD4, (iv) Defer initiation of ART for symptomatic TB patients, and (v) Tailored counselling to ensure optimal adherence to the advanced disease package [9]. This evidence concerns the gene CD4 and tuberculosis.