In this study, epigenetic regulator PRMT5 was shown to inhibit the transcriptional output of CAMK2N1 by depositing repressive histone marks H4R3me2s and H3R8me2s on the proximal promoter region of CAMK2N1, thus resulting in malignant progression of PCa both in vitro and in vivo. The gene discussed is PRMT5; the disease is posterior cortical atrophy.