PRMT5, as an oncogene, plays an indispensable regulatory role in the pathological progression of several human malignancies, including lung [44], gastric [45], breast cancer [46], lymphoma [47], leukemia [48] and glioblastoma [49], by depositing symmetric di-methylation marks on the arginine residues of substrates. The gene discussed is PRMT5; the disease is leukemia.