Also decreased level of VEGF was observed in the PGE (132.933 ± 21.607) and CFS (131.167 ± 22.990) groups compared with the VEN group (159.401 ± 25.578) (P < 0.01) at 4th day of CSE. This evidence concerns the gene VEGFA and myalgic encephalomeyelitis/chronic fatigue syndrome.