hypertension, diabetes, heart failure, COPD, cancer, CKD, PaO2/FiO2 < 200, CT signs of severe pneumoniae, lymphocytes < 0.6 × 103/μL, high D-dimer > 937 ng/mL, serum ferritin > 914 ng/mL, CRP > 6.3 mg/dL, LDH, eGFR, AST, ALT and FIB-4 > 3.25 (Supplementary Table 1). The gene discussed is CRP; the disease is chronic kidney disease.