Moreover, ANGPT1, EMCN, EMX2, ERG, HOXB9, ONECUT2 and SSTR1 were not only correlated with the clinical outcomes of VHL mutant ccRCC, but also were correlated with the clinical outcomes of all ccRCC in TCGA and E-MTAB-1980 datasets (Fig. 4e). This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.