Among those genes, ANGPT1, EMCN, EMX2, ERG, HOXB9, ONECUT2 and SSTR1 were differentially expressed in sub-cluster1 VHL mutant ccRCC in TCGA and E-MTAB-1980 datasets (Fig. 4a). The gene discussed is ANGPT1; the disease is nonpapillary renal cell carcinoma.