Consistent with the down-regulation of PBX1 in ccRCC tissues in TCGA dataset, in GSE36895, GSE40435, GSE46699, GSE47032, GSE53757, GSE66270, GSE68417 and GSE71963 datasets, PBX1 was down-regulated in ccRCC tissues, compared with the normal kidney tissues (Fig. 6a). This evidence concerns the gene PBX1 and nonpapillary renal cell carcinoma.