Moreover, the higher scores of DNA replication and homologous recombination were associated with the worse prognosis of VHL mutant ccRCC in TCGA (Fig. 2e) and E-MTAB-1980 (Supplementary Fig. 2a) datasets, while, the higher scores of WNT signaling pathway was associated with the better prognosis of VHL mutant ccRCC patients in TCGA (Fig. 2e) and E-MTAB-1980 (Supplementary Fig. 2a) datasets. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.