PBX1, EMCN and ERG were up-regulated in VHL mutant ccRCC with lower immune scores, compared with VHL mutant ccRCC with higher immune scores in TCGA dataset (Supplementary Fig. 3a), but not in E-MTAB-1980 dataset (Supplementary Fig. 3b). The gene discussed is PBX1; the disease is nonpapillary renal cell carcinoma.